NRXN1 and autism: According to the findings of Loers et al. (2023), L1 siRNA has an inhibitory effect on the expression of long-chain autism genes neurexin 1 (NRXN1) and neuroligin 1 (NLGN1) and mitochondrial-encoding genes such as NADH ubiquinone oxidoreductase core subunit 2 (ND2).