TRPA1 and irritable bowel syndrome: In the respiratory tract, TRPA1 is implicated in airway tissue injury and inflammation (Wang M. et al., 2019), whereas in the gastrointestinal tract, dysregulated TRPA1 activity in gut sensory neurons may contribute to inflammation observed in conditions such as irritable bowel syndrome (IBS) (Landini et al., 2022) and inflammatory bowel disease (IBD) (Kumar et al., 2022).