Beyond immediate defense mechanisms, the involvement of TRPA1 in fibroblast-myofibroblast transition and mediation of airway tissue injury underscores its significance in conditions such as severe asthma and fibrosis (Yang and Li, 2016; Li et al., 2020; Yap et al., 2021; Li et al., 2022). The gene discussed is TRPA1; the disease is asthma.