This osteoporosis may be attributed to the intracellular accumulation of iron, which induces G1 cell cycle arrest in osteoblasts, accompanied by downregulation of Cyclin D1, Cyclin D3, CDK2, CDK6, and CDK6 expression, thereby suppressing osteoblast proliferation (Cen et al., 2018). Here, CDK6 is linked to osteoporosis.