In 1968, research findings had already illuminated a substantial elevation in iron content within the synovial tissue of individuals grappling with RA (Senator and Muirden, 1968) More recently, scientific inquiries have unveiled a nuanced interplay involving the altered expression of iron-binding protein ferritin and diminished saturation of transferrin within the blood of RA patients (Tański et al., 2021). The gene discussed is TF; the disease is rheumatoid arthritis.