,28 Moreover, cholesterol synthesis has been strongly certified to regulate the stemness of tumor cells in breast cancer, bladder cancer, and colon cancer.13, 14, 15 Therefore, we can reasonably infer that the most possible regulatory mechanism is that high expression of HMGCR promotes the synthesis of cholesterol hydroxyl derivatives and subsequently facilitates the activation of SMO. Here, SMO is linked to malignant colon neoplasm.