The network of PDCD2 at the protein and gene levels in pan-cancer was shown in Figure 8A and 8B. After examined the association between these genes and PDCD2 in GBMLGG, we discovered a noteworthy positive correlation between PDCD2 and the expression of PDCD2L, NFKBIB, PRS2, and NFKB1 as depicted in Figure 9C. Additional analysis revealed that GBMLGG exhibited significant up-regulation of the four genes, which was associated with a poorer prognosis among patients (Fig. 8D, E). This evidence concerns the gene PDCD2 and cancer.