PDCD2 and acute leukemia: PDCD2 has been shown to be associated with B-cell malignant tumors and is regarded as a target gene of BCL6, and patients with acute leukemia can be monitored by PDCD2.8, 9, 10 Emerging evidence has indicated that PDCD2 acts as a tumor suppressor in gastrointestinal stromal tumors,11 liver cancer,12 and gastric cancer.13