CCND1 and familial pancreatic carcinoma: ,12,45, 46, 47 Our extensive research endeavors have firmly established FOXM1 as a crucial central gene that efficiently relays upstream regulations to downstream effectors (such as cyclin D1, vascular endothelial growth factor, and caveolin-1), which promotes angiogenesis, development, invasion, and metastasis in pancreatic cancer.9