IDH1 and glioblastoma: Taking a specific type of glioblastoma (GBM) as an example, the efficiency of generating and maintaining its corresponding patient-derived GBM-like organs (GBOs) is significantly lower compared to IDH1 wild-type tumors, revealing that the existing culture conditions and methods in these cases may need to be further fine-tuned and optimized to enhance the reliability and applicability of the organoid models [84].