Masson trichrome staining and Sirius Red staining showed that Syr decreased interstitial collagen accumulation and effectively reversed myocardial fibrosis in diabetic mice, and Syr significantly decreased the high expression of TGF-β, fibronectin, α-SMA, and p-Smad2/3 in cardiac tissues of diabetic mice. This evidence concerns the gene SMAD2 and Myocardial fibrosis.