AKT is the main downstream effector molecule of PI3K, which plays a key role in DCM by regulating cell size, survival, apoptosis, angiogenesis, and inflammatory response (Li et al., 2017; Qin et al., 2021; Ghafouri-Fard et al., 2022). This evidence concerns the gene AKT1 and familial dilated cardiomyopathy.