In this study, Syr, NGR1, SSYX, Soy isoflavone, Zicuitongmai Yin, ginkgolide B, and echinacoside could reduce myocardial fibrosis and improve DCM by regulating the TGF-β/Smad signaling pathway, which proves the great prospect of the TGF-β/Smad signaling pathway in TCM against myocardial fibrosis of DCM. This evidence concerns the gene YES1P1 and familial dilated cardiomyopathy.