Scutellaria barbata reduced GPX4 and SLC7A11 mRNA and protein levels to induce ferroptosis characterized by iron-mediated lipid peroxidation and ROS metabolism in hepatocellular carcinoma, thus suppressing HCC tumorigenicity in vivo (Li H. et al., 2022). The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.