GLS2 and gastric cancer: Physcion 8-O-β-glucopyranoside (PG), an anthraquinone extracted from Rumex japonicus Houtt. [Polygonaceae; R. japonicus root and fruit], upregulated ROS levels and intracellular Fe2+ levels by downregulating the inhibitory effect of miR-103a-3p on glutaminase 2 (GLS2) expression to induce ferroptosis of gastric cancer (Niu et al., 2019).