Agrimonolide is isolated from Agrimonia pilosa Ledeb. [Rosaceae; A. pilosa dried aerial parts]. It directly inhibited the stearoyl-CoA desaturase-1 (SCD1) protein to trigger ferroptosis of ovarian cancer, evidenced by the increased ROS, total iron, and Fe2+ levels and downregulation of ferroptosis inhibitors (SLC7A11 and GPX4), thus suppressing cancer progression in the SKOV-3 xenograft model (Liu et al., 2022). This evidence concerns the gene GPX4 and cancer.