Finally, to investigate a potential additive diagnostic value of the newly tested biomarkers to the currently established biomarkers of AKI staging (function biomarker + urine output) a second model for predicting AKI II/III combining SCr and urine output 6 h or CysC and urine output 6 h with urine osmolality, (TIMP-2) × (IGFBP7) or suPAR was performed (Figure 3). Here, TIMP2 is linked to acute kidney injury.