In this study, we found that AOF was able to reduce GLU, mAlb, Scr, BUN, MDA, SOD, and renal pathological tissue damage in DKD mice, reduce the expression of P16, P21, P53 mRNA, and protein, and reduce the expression of SASP (IL-6, IL-1β, TGF-β, MMP3, and MCP1) mRNA. This evidence concerns the gene TP53 and diabetic kidney disease.