In this study, we found that AOF was able to reduce GLU, mAlb, Scr, BUN, MDA, SOD, and renal pathological tissue damage in DKD mice, reduce the expression of P16, P21, P53 mRNA, and protein, and reduce the expression of SASP (IL-6, IL-1β, TGF-β, MMP3, and MCP1) mRNA. The gene discussed is CCL2; the disease is diabetic kidney disease.