In addition, since immune-inflammatory infiltration is a key factor in inducing the acquisition of a cellular senescence phenotype, we observed the presence of immune-inflammatory cell infiltration in the renal tissues of the mice in the model group by HE staining, and elisa also detected an increase in the levels of IL-6, IL-1β in the renal tissues; whereas, AOF could ameliorate the immune-inflammatory infiltration in the kidneys of the mice with DKD, and reduce the levels of inflammatory factor expression. The gene discussed is IL6; the disease is diabetic kidney disease.