To further elaborate the shared pathways between IS and MS, we further compared the immune infiltration and metabolic pathways between the two groups and found the stroke group has a lower infiltration of B cells (naive, memory), T cells (CD8, CD4 naive) and enrichment of neutrophils, M0 macrophages and monocytes suggesting that IS group has immune deficiency and inflammation phenotype. This evidence concerns the gene CD4 and myeloid sarcoma.