To further elaborate the shared pathways between IS and MS, we further compared the immune infiltration and metabolic pathways between the two groups and found the stroke group has a lower infiltration of B cells (naive, memory), T cells (CD8, CD4 naive) and enrichment of neutrophils, M0 macrophages and monocytes suggesting that IS group has immune deficiency and inflammation phenotype. The gene discussed is CD8A; the disease is stroke disorder.