Nonetheless, the most recent meta-analysis revealed substantial heterogeneity in certain comparisons but no significant differences in cytokines, such as IL-1β, IL-6, IL-8, IL-10, or TNF-α, were discovered between AD patients and healthy controls (Blennow and Hampel, 2003; Newcombe et al., 2018). The gene discussed is TNF; the disease is Alzheimer disease.