Furthermore, a combination of soluble IL-6 receptor (sIL-6R), tissue inhibitor of metalloproteinases-1 (TIMP-1), and soluble TNF-α receptor I (sTNFR-I) in CSF was found to provide the best prediction to AD among other molecules after screening 120 inflammatory molecules in CSF and serum of AD, MCI, and healthy controls using protein-array analysis (Richens et al., 2014; Delaby et al., 2015). This evidence concerns the gene TIMP1 and Alzheimer disease.