MAPT and Alzheimer disease: According to Newcombe et al. (2018), the pathogenesis of AD may be advanced by the microglia’s continuous brain stimulation in response to the accumulation of Aβ plaque, tau protein phosphorylation, and inflammatory responses which impairs their ability to phagocytose, produces pro-inflammatory mediators, and exacerbates tau and Aβ pathology (Leng and Edison, 2020).