Cluster analysis, timeline visualization, and burst analysis of keywords revealed that recent studies focused on depression, covid-19, HIV-associated neurocognitive disorders, neurofilament light chain, blood-brain barrier, hypercytokinemia, maternal immune activation, gut microbiota, stress, neuropathology and other directions, indicating that these areas are potential future research frontiers in the field of the virus, neuroinflammation and psychiatric disorders (Figures 8D–F). The gene discussed is NEFL; the disease is major depressive disorder.