TSH, BMIFasting plasma glucose and insulin will be measured to derive the Homeostasis Model Assessment (HOMA) score, indicating glucose tolerance and insulin resistance. For non-diabetic patients, an oral glucose tolerance test (OGTT) will be conducted with samples taken at 0, 30, and 120 min. These measurements will help calculate indices for insulin sensitivity, secretion, and gauge glucose tolerance, including potential impaired glucose tolerance. Additionally, HbA1c will be assessed.Lipid profile (LDL, HDL, TG, cholesterol). The gene discussed is INS; the disease is Insulin resistance.