GPX4 and kidney disorder: Therefore, studying the potential antagonistic or synergistic effects of ferroptosis in the context of kidney disease is necessary; (2) Currently, research on ferroptosis is based on various disease models, and the impact of ferroptosis on renal fibrosis under physiological conditions is not yet clear; (3) Although regulatory factors of ferroptosis such as ROS, GPx4, GSH, and iron metabolism have been described, they do not constitute suitable sensitive biomarkers for monitoring ferroptosis.