(2) Saponins: Astragaloside IV, an active component of Astragalus, activates the PI3K/AKT and Nrf2 signaling pathways, reduces oxidative stress, enhances GPX4 and Nrf2 expression, reduces iron accumulation, inhibits ferroptosis induced by Aflatoxin, significantly improves kidney damage, and protects kidney cells (178). This evidence concerns the gene NFE2L2 and Nephropathy.