Research has shown that centelloside selectively regulates the Nrf2 pathway, increasing the expression of Nrf2, GPX4, and SLC7A11 in a kidney injury model, inhibiting oxidative stress and ferroptosis, alleviating LPS-induced vacuolation and glomerular mesangial expansion in kidney tissues, to reduce AKI (188). The gene discussed is NFE2L2; the disease is acute kidney injury.