Therefore, studying the potential antagonistic or synergistic effects of ferroptosis in the context of kidney disease is necessary; (2) Currently, research on ferroptosis is based on various disease models, and the impact of ferroptosis on renal fibrosis under physiological conditions is not yet clear; (3) Although regulatory factors of ferroptosis such as ROS, GPx4, GSH, and iron metabolism have been described, they do not constitute suitable sensitive biomarkers for monitoring ferroptosis. Here, GPX4 is linked to renal fibrosis.