Hyperglycemic states have been shown to reduce both neutrophils’ opsonophagocytosis (OP) activity and superoxide dismutase (SOD) production.7,42 In a study of 10 adults with type 2 diabetes mellitus, it was found that for baseline glycemic conditions, their neutrophils did not have defective OP activity. The gene discussed is SOD1; the disease is type 2 diabetes mellitus.