When placed in either 60 mM glucose (upper range during diabetic ketoacidosis), 120 mM glucose (representing modest hyperglycemic levels), or 60mM choline chloride (a GBS osmolyte), it was shown that both OP and SOD production decreased under hyperglycemic conditions and that administration of type III antibodies improved OP.42 The gene discussed is SOD1; the disease is diabetic ketoacidosis.