Moreover, unequivocal strong diffuse membranous CD 99 positivity along with strong nuclear NKX2.2 positivity as well as diffuse cytoplasmic positivity for Vimentin and NSE and focal positivity for Synaptophysin helped in clinching the diagnosis of metastatic deposits of ES in the submandibular lymph node. This evidence concerns the gene ENO2 and Ewing sarcoma.