PRNP and Creutzfeldt Jacob disease: Infectious cases are through the transmission of prion, and iatrogenic cases by corneal transplant, EEG and EMG electrode implantation, and dura mater grafts have also been reported.5 Variant CJD has been reported in young adults in Europe due to exposure to tainted beef from cattle with bovine spongiform encephalopathy.6 The genetic susceptibility to this disease is explained by the mutation of the PRNP gene located in the short arm of chromosome 20.7