We examined a collection of 13 neuroblastoma cell lines (Fig. 1A) for levels of PRMT5, E2F1 and MYCN which subsequently allowed us to broadly divide them into high PRMT5, E2F1 and MYCN expressors (CHP‐134, KELLY, SK‐N‐BE, LAN‐5 and SMS‐KCNR cells) or low expressors of PRMT5, E2F1 and MYCN (GI‐ME‐N, SHEP‐2, SH‐SY5Y and LAN‐6 cells). The gene discussed is E2F1; the disease is neuroblastoma.