Indeed, in previous studies of colorectal cancer, tumour cells at the invasive margin were detected with lower Ki67 expression, and budding tumour cells exhibited EMT‐like phenotypes and lower Ki67 positivity compared to tumour bulk,43, 44 while highly proliferative tumours possessed fewer invasive subclones, corresponding to a lower risk of metastasis.45 Here, MKI67 is linked to neoplasm.