In hypoxic microenvironment, neutrophils of branching‐two tumours were closely related to macrophages, which not only encouraged macrophage to convert to M2‐TAM phenotype,37, 38 but mediated adhesion and crosstalk with macrophage through ICAM‐1 (Figure 5F), and elevated expression of ICAM‐1 in macrophages had been reported to be associated with more aggressive tumours.39 The gene discussed is ICAM1; the disease is neoplasm.