We discovered that neutrophils located with cancer cells through desmosomal junctions and transmitted VEGF signalling to endothelial cells to promote angiogenesis, which was consistent with the recent researches that neutrophils played a crucial role in tumour development, not only by recruiting and stabilizing tumour cells, but also by participating in neovascularization to facilitate tumour progression.47, 48. Here, VEGFA is linked to neoplasm.