We subsequently treated the cells with actinomycin D. The degradation of ANKRD22 mRNA was significantly accelerated in IGF2BP2 knockdown NPC cells compared with control cells (Figure 5E), which inhibited the effect of METTL14 overexpression on the degradation rate of ANKRD22 mRNA (Figure 5F). This evidence concerns the gene ANKRD22 and nasopharyngeal carcinoma.