On one hand, ANKRD22 enhanced histone H3 lysine 27 acetylation (H3K27AC) near the promoters of genes related to the cell cycle and cytoskeleton, including GINS Complex Subunit 3 (GINS3), DNA Polymerase Epsilon 2 (POLE2), Pleckstrin 2 (PLEK2) and FERM Domain Containing Kindlin 1 (FERMT1), thereby promoting proliferation and metastasis of NPC. The gene discussed is POLE2; the disease is nasopharyngeal carcinoma.