METTL14 and nasopharyngeal carcinoma: To delve further into the mechanism by which METTL14 regulates ANKRD22 expression in NPC, we treated cells with the transcriptional inhibitor actinomycin D. It revealed that overexpression of METTL14 resulted in a slower degradation of ANKRD22 mRNA, while knockdown of METTL14 accelerated the degradation of ANKRD22 mRNA (Figure 4A).