Gene and pathway analysis on the female cohort revealed enrichment several pathways in the analyses including symptom variations, with genes associated with transcriptional activities, growth factors, alcoholism pathways, DNA maintenance and targets of IRF7, IRF2 and AUTS2. IRF7 plays an important role in immunity and autoimmunity [65], while IRF2 is involved in inflammatory and cancer pathogenesis [66]. The gene discussed is AUTS2; the disease is alcohol dependence.