Using a similar approach in 34 depressed patients, Sirignano et al. [9] found significant differentially methylated cytosine-phosphate-guanine dinucleotide (CpG) sites associated with binary or continuous response to ECT, highlighting TNKS, associated with MDD and other psychiatric diseases, and FKBP5, which regulates the stress–response system being linked to psychiatric disorders, including MDD. This evidence concerns the gene TNKS and major depressive disorder.