The pathological hallmarks of AD include amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs), such as tau protein tangles [4], cholinergic dysfunction [5], glial cell activation [6], mitochondrial dysfunction [7], vascular abnormalities [8], calcium homeostasis [9], oxidative stress [10], and synaptic dysfunction [11]. This evidence concerns the gene MAPT and Alzheimer disease.