Moreover, it has been proposed that the glycolytic enzyme and plasminogen receptor alpha-enolase (ENO1) as well as the transcription factor far upstream element-binding protein 1 (FUBP1) were upregulated in PC patients, leading to the production of autoantibodies (aAb) that discriminate healthy subjects from PC patients. The gene discussed is ENO1; the disease is pachyonychia congenita.