Under the influence of oxidative stress, hypoxia, cytokines, growth factors released by tumor cells such as PDGF, TGF-β1 and specific signaling pathways (PI3-AKT, Wnt, JAK/STAT, and sonic hedgehog-Gli1), PSCs are recruited by the BM and from a quiescent state become activated [102]. This evidence concerns the gene TGFB1 and neoplasm.