A view of the key role of the Wnt/β-catenin signaling pathway in colon cancer progression and its potential for long-term activation to drive CAC development [26], this study further employed the IHC method to verify the expression of β-catenin and its downstream proteins Cyclin D1 and c-Myc in mouse colon tissue. The gene discussed is CCND1; the disease is colonic neoplasm.