Notably, in the five tumours with detected SBS3 (OESO_0113, OESO_0040, OESO_0125, OESO_0025 and OESO_0008), only private mutations were assigned to the BRCA signature (SBS3), but no non-synonymous mutations in BRCA1/2 were found. This evidence concerns the gene BRCA1 and neoplasm.