The pDCs migrate in response to the stromal cell–derived factor 1 (SDF-1/CXCL12), a homeostatic chemokine expressed by HEV [88, 89], but also detected in melanoma [43, 90], oral squamous cell carcinoma (OSCC) [91, 92], ovarian cancer [93], breast cancer and metastatic lymph nodes [94, 95], underlining its role in pDC recruitment to tumor sites [87, 88, 93]. The gene discussed is CXCL12; the disease is oral cavity squamous cell carcinoma.