Despite many studies suggested a downregulation or loss of chemerin in various tumors compared to the normal tissue counterparts [102], upregulation of chemerin was found in gastric cancer [103, 104], mesothelioma [105], neuroblastoma [106] and cervical neoplastic lesions [107], suggesting that chemerin in the TME might have context-dependent effects on tumorigenesis and tumor progression. Here, RARRES2 is linked to neoplasm.