Type I IFNs are a class of proinflammatory cytokines (i.e. including 13 genes coding for IFN-α, and individual gene coding for IFN-β, IFN-ω, IFN-ɛ, and IFN-к) that have context-dependent functions on cancer immunosurveillance and immunoediting [108]. The gene discussed is IFNA1; the disease is cancer.