Since the stability of β-catenin is regulated mainly by the ubiquitination–proteasome degradation pathway [24], we examined the β-catenin levels in various groups in the presence of the proteasome inhibitor MG132 and found that β-catenin degradation could be prevented in THBS2-silenced CRC cells (Figs. 4B). Here, THBS2 is linked to colorectal carcinoma.