In addition to the function of THBS2 in CRC cells, our study revealed a dual function of THBS2 in regulating CRC metastasis: one function is to activate the intrinsic Wnt pathway in CRC cells to trigger distant metastasis, and the other is to induce TAM M2 polarization for a prometastatic TME after transmission in the form of exosomes. This evidence concerns the gene THBS2 and colorectal carcinoma.