Out of 800 men and postmenopausal women with T2DM solicited for participation, 25 declined, 36 lacked essential laboratory data or had severe cardiac, hepatic, renal disease or thyroid dysfunction, 74 were premenopausal women, and 114 possessed a variant SHBG SNP at rs6257 or rs6259. This evidence concerns the gene SHBG and type 2 diabetes mellitus.