To further explore the biological effects of SH3PXD2A-AS1 on DDP resistance, results of knockdown experiments showed that silencing SH3PXD2A-AS1 in A549/DDP and H1299/DDP cell lines suppressed the cell viability and elevated apoptosis, implying that lack of SH3PXD2A-AS1 made DDP-resistant NSCLC cells more sensitive to DDP. Here, SH3PXD2A is linked to non-small cell lung carcinoma.