In addition, tumor-derived function of tumor protein P63 (TP63), a master transcription factor in SCC, in promoting immune evasion and influencing the efficacy of immunotherapy in squamous carcinoma, revealing that IFNγ/α signaling is the pathway that is most significantly inhibited by TP63, which is usually specifically overexpressed in SCC, and that in human SCC patients, TP63 expression was negatively correlated with CD8 + T cell infiltration and activation [26]. The gene discussed is CD8A; the disease is squamous cell carcinoma.