2- sample MR analysis indicated suggestive causal relationships of inflammatory cytokines, such as IL-10 (OR = 0.919; P = 0.049), Eotaxin (OR = 0.927; P = 0.047), IFN-γ (OR = 0.852; P = 0.009) and SCGF-β (OR = 1.064; P = 0.044) on endometrial cancer risk (Fig. 1). This evidence concerns the gene IFNG and endometrial cancer.