We identified 10 genes across chromosomes 1, 2, and 3: MACF1, C1orf185, PTGFRN, NOTCH2, ABCB10, GCKR, THADA, RBMS1, SPHKAP, and PPARG. Genes such as GCKR and PPARG emphasize the metabolic connection between T2DM and GBM. This evidence concerns the gene C1orf185 and glioblastoma.