According to the results in Fig. 7c, d, SELENOW-AD mice had a significant decrease in tau phosphorylated at epitope Ser396 and Ser404, but no changes were observed for tau phosphorylated at epitopes Thr181, Ser202/Thr205, Thr231, Ser262, Ser416 and Ser422. This evidence concerns the gene MAPT and Alzheimer disease.