48 individuals carried cardiovascular disease-related pVUS variants (c.2477 T > C (p.Leu826Ser) in DSG2, c.223 C > A (p.Gln75Lys) in MYL3, c.5065 C > A (p.Arg1689Ser) in MYH7, c.326 T > G (p.Val109Gly) in LMNA, c.77035 A > C (p.Asn25679His) in TTN, and c.10255 T > C (p.Phe3419Leu) in RYR2) and reported cardiovascular phenotypes (self-reported history of personal and parents heart disease, and parents’ cause of death was related to heart disease) (Supplementary Table 2, Additional File 2). Here, RYR2 is linked to heart disorder.