RYR2 and cardiovascular disorder: 48 individuals carried cardiovascular disease-related pVUS variants (c.2477 T > C (p.Leu826Ser) in DSG2, c.223 C > A (p.Gln75Lys) in MYL3, c.5065 C > A (p.Arg1689Ser) in MYH7, c.326 T > G (p.Val109Gly) in LMNA, c.77035 A > C (p.Asn25679His) in TTN, and c.10255 T > C (p.Phe3419Leu) in RYR2) and reported cardiovascular phenotypes (self-reported history of personal and parents heart disease, and parents’ cause of death was related to heart disease) (Supplementary Table 2, Additional File 2).