In hepatocellular carcinoma (HCC), lncRNA HOXA-AS3 was reported to promote cell metastasis, EMT and proliferation via enhancing the activation of the mitogen-activated protein kinase (MAPK) and extracellular regulated protein kinase (ERK) through sponging miR-29c28. The gene discussed is PDS5B; the disease is hepatocellular carcinoma.