Individuals who have systemic obesity and exhibit elevated levels of peroxisome proliferator-activated receptor-γ (PPARγ) metabolites exhibit adipose infiltration into the bone marrow and diminished differentiation of the common progenitor to osteoblasts.48.In addition, obesity can contribute to the reduction of bone and osteoblast by inducing the differentiation of adipocytes from bone marrow mesenchymal stem cells49. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.