To gain further understanding of the importance of the ID2-ETS2 transcriptional regulatory axis in the acquisition of the C6 glioma cells induced tumour-supportive phenotype in BV2 microglia, Id2 or Ets2 gene expression were transiently repressed in BV2 microglia prior to their exposure to C6 glioma cells. The gene discussed is ETS2; the disease is central nervous system cancer.