In search of a pathophysiological relevance for the microglial transcriptional regulatory ID2-ETS2 axis we uncovered, we took advantage of an available human genome-wide gene expression dataset that investigated by single-cell RNA-sequencing in 18 glioma tumours, including 11 newly diagnosed GB, (characterized as IDH1-wildtype), the transcriptomes of the malignant neoplastic cells, and of the immune cells, including microglia and macrophages, within the tumour microenvironment [22]. Here, ID2 is linked to central nervous system cancer.