After having demonstrated in BV2 microglia stimulated by C6 glioma cells, an upregulation of two transcription regulatory cofactors, i.e., ID1 and ID2, we thought to identify the transcription factors that could contribute to the acquisition of the microglial tumour-supportive gene expression signature, and whose transcriptional activities could be regulated by interactions with ID proteins. Here, ID1 is linked to central nervous system cancer.