We next applied this predictive tool to examine two sets of public RNA-seq data: one from human bone osteosarcoma epithelial U2OS cells before and after CSB KD (Supplementary Fig. 9a, b)45 and another from CS patient-derived fibroblasts (CS1AN), which were either rescued by wild-type CSB cDNA or left untreated (Supplementary Fig. 9c, d)7. The gene discussed is ERCC6; the disease is bone osteosarcoma.