CD274 and hepatocellular carcinoma: To further explore whether TNKS1BP1 knockdown could sensitize HCC to anti-PD-L1 immunotherapy, we applied bioinformatic analysis and found significant negative correlations between TNKS1BP1 expression level and the infiltration level of most types of T cells, especially CD8+ T cells, in the TCGA LIHC cohort (Fig. S7C).