CNOT4 and hepatocellular carcinoma: To investigate the mechanisms TNKS1BP1 participated in malignant biological behaviors of HCC cells, we looked for TNKS1BP1 interacting proteins in the GeneMANIA database (https://genemania.org/) [29] and the result showed that CNOT4 had an interaction with TNKS1BP1 (Fig. S4A).