In the TCGA liver hepatocellular carcinoma (LIHC) dataset, we found that the mRNA levels of TNKS1BP1 were upregulated in human HCC samples compared with normal counterparts (Fig. 1A), and higher expression of TNKS1BP1 was associated with shorter overall survival (OS) in HCC (Fig. 1B). The gene discussed is CNOT12; the disease is hepatocellular carcinoma.