TRMT2A and neoplasm: For example, TRMT2A-mediated 5-methyluridine (m5U) tRNA methylation can affect cell proliferation, TRMT2A localizes in the nucleus, possibly modifying tRNA in the nucleus, and TRMT2A inhibits cell proliferation blocking it in the G2/M phase, and knockout TRMT2A in MEF cells can promote MEF cell proliferation, suggesting that TRMT2A-mediated m5U tRNA modification may inhibit tumor cell growth [98].