METTL1 and neoplasm: For instance, a recent study has demonstrated that numerous genes that promote the cell cycle and tumor metastasis are abundant in AGA codons, such as CDK4, HMGA2, and others, and the overexpression of these AGA codon-rich genes, which happens due to METTL1-dependency, has been discovered in several tumors like AML, glioblastoma, and liposarcoma that may as well overexpress METTL1.