SACK1A and pancreatic neoplasm: Another study showed that disrupting the interaction of FAM83A with β-catenin using inhibitory peptide to prevent pancreatic cancer progression, and FAM83A directly binds to β-catenin to inhibit β-catenin phosphorylation thereby promoting β-catenin entry into the nucleus, enhancing the transcription of Wnt downstream target genes and promoting pancreatic cancer progression [175].