NSUN6 and cancer: Thus, making it exactly which RNA modifications are dominant for cancer cell survival still lacks strong evidence to support, for example NSUN6 as m5C methyltransferase of mRNA and tRNA is significantly upregulated in pancreatic cancer cells and promotes pancreatic cancer cell progression [97], but still no detailed elucidation of which RNAs are most important for NSUN6-mediated m5C modifications.