EIF2AK3 and colorectal cancer: However, in line with previous publications (44) a signaling upregulation of pERK mediated by an overexpression of EGFR was observed after 24 hours of BRAF blockade and reduced with the doublet in the BRAFV600E colorectal cancer PDXO model [Supplementary Fig. S5A; Fig. 3D (right)].