For example, the authors noted that their PRS included variants that have been linked individually to tau aggregation, including a BIN1 variant, which interacts with Aβ load to accelerate tau accumulation.10 Studies that integrate regional gene expression data could add further support to the role of specific genes in the Alzheimer’s disease cascade, for example by testing spatial correlations with regions prone to Aβ or tau aggregation. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.