The fibrosis marker collagen I (encoded by Col1a1) and the inflammatory marker toll-like receptor 4 (TLR4, encoded by Tlr4) were both upregulated in DCM-dnPI3K atria versus Ntg, but were not different in IGF1R atria (Figure 5C,D). The gene discussed is TLR4; the disease is familial dilated cardiomyopathy.