A greater number of proteins were differentially abundant in the atria of DCM-dnPI3K versus Ntg mice (652 up-regulated, 958 down-regulated; Figure 6Bii, iii; Supplementary Tables 3.4 and 3.4i), which was not unexpected given the more pronounced functional and histological phenotype in the pathological model. The gene discussed is OPA1; the disease is familial dilated cardiomyopathy.