However, the potential role of the RBP/GIGYF1/eIF3 mechanism of translational control and the p38 and JNK-mediated S638 phosphorylation of GIGYF1 in maintaining the delicate balance between promoting the antiviral response and preventing an unrestrained proinflammatory reaction during viral infections necessitates further investigation in future studies. Here, EIF3A is linked to viral infectious disease.