EP300 and colorectal cancer: We then analyzed epigenomic datasets from the HCT116 colorectal cancer cell line (3, 29–31) and found that LTR10A and LTR10F elements exhibit canonical chromatin hallmarks of enhancer activity, including enrichment of histone modifications histone H3 lysine 27 acetylation (H3K27ac) and histone H3 lysine 4 monomethylation (H3K4me1), the transcriptional coactivator p300, and RNA polymerase II occupancy (Fig. 1G).