To assess the potential roles of spliceosomal Sm proteins in human cancer, seven well‐established Sm factors [SNRPD1 (PD1), PD2, SNRPD3 (PD3), SNRPB (PB), SNRPE (PE), SNRPF (PF) and SNRPG (PG)] were selected for investigation. The gene discussed is PAF1; the disease is cancer.