One study revealed that digitoxin inhibits the interaction of NFAT1 with the proximal MYC promoter to suppress MYC transcription.[28] Another study reported that bufanolides have similar effects as digitoxin and play an antiproliferative role via MYC suppression.[29] Our study confirmed that targeting feedback circuits is a possible mechanism by which digitoxin acts as an anticancer agent with selectivity for cancers driven by MYC signaling. The gene discussed is NFATC2; the disease is cancer.