Although the prognostic potential of Sm proteins, including SmD1 and SmE, has been reported, the expression profiles of these proteins in cancer and the detailed mechanisms underlying how they function are largely unclear.[5] Through analysis of The Cancer Genome Atlas (TCGA), we found that the 7 Sm genes are differentially expressed in cancers; SNRPD2 (PD2) is the most highly expressed Sm gene, suggesting its potential oncogenic role in a Sm ring‐independent mechanism. Here, PAF1 is linked to cancer.