Sm proteins are related to the prognosis of some cancers; however, the detailed roles and regulatory mechanisms of them are unclear.[10] To evaluate the key Sm protein in HCC, we silenced their expression in Huh7, HCCLM3, SMMC7721, or SNU449 cells (Figure S1b, Supporting Information), and the results showed that silencing PD2 expression markedly inhibited the growth of cells, while the effect was less pronounced when other Sm genes were silenced (Figure 1c; Figure S1c, Supporting Information). Here, PAF1 is linked to hepatocellular carcinoma.