We observed that the protein levels of CDC20 and BUBR1 were decreased by ≈50% in CCDC68‐knockout HCT116 cells during late prometaphase (Figure 6E; Figure S8F–J, Supporting Information), suggesting that CDC20 and BUBR1 protein levels were at least partly maintained by CCDC68 in cancer cells with low aneuploidy rates. The gene discussed is BUB1B; the disease is cancer.