Enhanced glycolysis and lactate accumulation are common features of various cancers,[25, 32, 33] and intracellular lactate drives a recently described type of protein modification, lysine lactylation.[18] A previous lactylome analysis of hepatitis B virus‐related hepatocellular carcinoma (HCC) has broadened our knowledge of the molecular events associated with this fatal malignancy.[34] However, whether and how protein functions are regulated by lactylation modifications require further elucidation, especially regarding the molecular dynamics of Kla regulation in distinct GI tumors. This evidence concerns the gene KL and cancer.