Enhanced glycolysis and lactate accumulation are common features of various cancers,[25, 32, 33] and intracellular lactate drives a recently described type of protein modification, lysine lactylation.[18] A previous lactylome analysis of hepatitis B virus‐related hepatocellular carcinoma (HCC) has broadened our knowledge of the molecular events associated with this fatal malignancy.[34] However, whether and how protein functions are regulated by lactylation modifications require further elucidation, especially regarding the molecular dynamics of Kla regulation in distinct GI tumors. The gene discussed is KL; the disease is hepatocellular carcinoma.